EC 2.5.1.149 - Lycopene elongase/hydratase (flavuxanthin-forming)

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IntEnz Enzyme Nomenclature
EC 2.5.1.149

Names

Accepted name:
lycopene elongase/hydratase (flavuxanthin-forming)
Systematic name:
dimethylallyl-diphosphate:all-trans-lycopene dimethylallyltransferase (hydrating, flavuxanthin-forming)

Reactions

Comments:

The enzyme, characterized from the bacterium Corynebacterium glutamicum, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2, as well as the hydroxylation of the new isoprene unit. The enzyme acts at both ends of the substrate, forming the C50 carotenoid flavuxanthin via the C45 intermediate nonaflavuxanthin. cf. EC 2.5.1.150, lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Krubasik, P., Kobayashi, M., Sandmann, G.
    Expression and functional analysis of a gene cluster involved in the synthesis of decaprenoxanthin reveals the mechanisms for C50 carotenoid formation.
    Eur. J. Biochem. 268 : 3702-3708 (2001). [PMID: 11432736]
  2. Heider, S. A., Peters-Wendisch, P., Wendisch, V. F.
    Carotenoid biosynthesis and overproduction in Corynebacterium glutamicum.
    BMC Microbiol. 12 : 198 (2012). [PMID: 22963379]

[EC 2.5.1.149 created 2018]