EC - Lycopaoctaene synthase

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IntEnz Enzyme Nomenclature


Accepted name:
lycopaoctaene synthase
Systematic name:
geranylgeranyl diphosphate:geranylgeranyl diphosphate geranylgeranyltransferase



The enzyme, characterized from the green microalga Botryococcus braunii race L, in involved in biosynthesis of (14E,18E)-lycopadiene. In vitro, the enzyme can accept (2E,6E)-farnesyl diphosphate and phytyl diphosphate as substrates, and is also able to catalyse the condensation of two different substrate molecules, forming chimeric products. However, the use of these alternative substrates is not significant in vivo.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Thapa, H. R., Naik, M. T., Okada, S., Takada, K., Molnar, I., Xu, Y., Devarenne, T. P.
    A squalene synthase-like enzyme initiates production of tetraterpenoid hydrocarbons in Botryococcus braunii Race L.
    Nat Commun 7 : 11198 (2016). [PMID: 27050299]
  2. Thapa, H. R., Tang, S., Sacchettini, J. C., Devarenne, T. P.
    Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L.
    ACS Chem. Biol. 12 : 2408-2416 (2017). [PMID: 28813599]

[EC created 2018]