EC 2.5.1.146 - 3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.146

Names

Accepted name:
3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase
Other name:
famD2 (gene name)
Systematic name:
geranyl-diphosphate:3-[(Z)-2-isocyanoethenyl]-1H-indole geranyltransferase

Reaction

Comments:

The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Li, S., Lowell, A. N., Yu, F., Raveh, A., Newmister, S. A., Bair, N., Schaub, J. M., Williams, R. M., Sherman, D. H.
    Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.
    J. Am. Chem. Soc. 137 : 15366-15369 (2015). [PMID: 26629885]

[EC 2.5.1.146 created 2018]