EC 2.5.1.137 - 2-acyl-4-prenylphloroglucinol 6-prenyltransferase

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IntEnz Enzyme Nomenclature
EC 2.5.1.137

Names

Accepted name:
2-acyl-4-prenylphloroglucinol 6-prenyltransferase
Other names:
PT2 (gene name)
aromatic prenyltransferase [ambiguous]
Systematic name:
dimethylallyl diphosphate:2-acyl-4-prenylphloroglucinol 6-dimethylallyltransferase

Reactions

Cofactor

Comments:

The enzyme, characterized from hop (Humulus lupulus), catalyses two successive prenylations of a 2-acyl-4-prenylphloroglucinol during the synthesis of bitter acids. Forms a complex with EC 2.5.1.136, 2-acylphloroglucinol 4-prenyltransferase, which catalyses the initial prenylation of the substrates. Requires Mg2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Li, H., Ban, Z., Qin, H., Ma, L., King, A. J., Wang, G.
    A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.
    Plant Physiol. 167 : 650-659 (2015). [PMID: 25564559]

[EC 2.5.1.137 created 2017]