EC 2.5.1.136 - 2-acylphloroglucinol 4-prenyltransferase

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IntEnz Enzyme Nomenclature
EC 2.5.1.136

Names

Accepted name:
2-acylphloroglucinol 4-prenyltransferase
Other names:
PT-1 (gene name)
PT1L (gene name)
aromatic prenyltransferase [ambiguous]
Systematic name:
dimethylallyl diphosphate:2-acylphloroglucinol 4-dimethylallyltransferase

Reactions

Cofactor

Comments:

The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC 2.5.1.137, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Tsurumaru, Y., Sasaki, K., Miyawaki, T., Uto, Y., Momma, T., Umemoto, N., Momose, M., Yazaki, K.
    HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops.
    Biochem. Biophys. Res. Commun. 417: 393-398 (2012). [PMID: 22166201]
  2. Li, H., Ban, Z., Qin, H., Ma, L., King, A. J., Wang, G.
    A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.
    Plant Physiol. 167: 650-659 (2015). [PMID: 25564559]

[EC 2.5.1.136 created 2017]