EC - 2-acylphloroglucinol 4-prenyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
2-acylphloroglucinol 4-prenyltransferase
Other names:
PT-1 (gene name)
PT1L (gene name)
aromatic prenyltransferase [ambiguous]
Systematic name:
dimethylallyl diphosphate:2-acylphloroglucinol 4-dimethylallyltransferase




The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Tsurumaru, Y., Sasaki, K., Miyawaki, T., Uto, Y., Momma, T., Umemoto, N., Momose, M., Yazaki, K.
    HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops.
    Biochem. Biophys. Res. Commun. 417: 393-398 (2012). [PMID: 22166201]
  2. Li, H., Ban, Z., Qin, H., Ma, L., King, A. J., Wang, G.
    A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway.
    Plant Physiol. 167: 650-659 (2015). [PMID: 25564559]

[EC created 2017]