EC 2.5.1.135 - Validamine 7-phosphate valienyltransferase

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IntEnz Enzyme Nomenclature
EC 2.5.1.135

Names

Accepted name:
validamine 7-phosphate valienyltransferase
Other names:
vldE (gene name)
valL (gene name)
Systematic name:
GDP-valienol:validamine 7-phosphate valienyltransferase

Reaction

Comments:

The enzyme, characterized from several Streptomyces strains, is involved in the biosynthesis of the antifungal agent validamycin A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Asamizu, S., Yang, J., Almabruk, K. H., Mahmud, T.
    Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
    J. Am. Chem. Soc. 133: 12124-12135 (2011). [PMID: 21766819]
  2. Zheng, L., Zhou, X., Zhang, H., Ji, X., Li, L., Huang, L., Bai, L., Zhang, H.
    Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis.
    PLoS ONE 7: e32033 (2012). [PMID: 22384130]
  3. Cavalier, M. C., Yim, Y. S., Asamizu, S., Neau, D., Almabruk, K. H., Mahmud, T., Lee, Y. H.
    Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex.
    PLoS ONE 7: e44934 (2012). [PMID: 23028689]

[EC 2.5.1.135 created 2016]