EC 2.5.1.130 - 2-carboxy-1,4-naphthoquinone phytyltransferase

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IntEnz Enzyme Nomenclature
EC 2.5.1.130

Names

Accepted name:
2-carboxy-1,4-naphthoquinone phytyltransferase
Other names:
menA (gene name)
ABC4 (gene name)
1,4-dioxo-2-naphthoate phytyltransferase
1,4-diketo-2-naphthoate phytyltransferase
Systematic name:
phytyl-diphosphate:2-carboxy-1,4-naphthoquinone phytyltransferase

Reaction

Comments:

This enzyme, founds in plant and cyanobacteria, catalyses a step in the synthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme catalyses the transfer of the phytyl chain synthesized by EC 1.3.1.83, geranylgeranyl diphosphate reductase, to 2-carboxy-1,4-naphthoquinone.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Johnson, T. W., Shen, G., Zybailov, B., Kolling, D., Reategui, R., Beauparlant, S., Vassiliev, I. R., Bryant, D. A., Jones, A. D., Golbeck, J. H., Chitnis, P. R.
    Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803.
    J. Biol. Chem. 275: 8523-8530 (2000). [PMID: 10722690]
  2. Shimada, H., Ohno, R., Shibata, M., Ikegami, I., Onai, K., Ohto, M. A., Takamiya, K.
    Inactivation and deficiency of core proteins of photosystems I and II caused by genetical phylloquinone and plastoquinone deficiency but retained lamellar structure in a T-DNA mutant of Arabidopsis.
    Plant J. 41: 627-637 (2005). [PMID: 15686525]

[EC 2.5.1.130 created 2015]