EC - N4-bis(aminopropyl)spermidine synthase

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IntEnz Enzyme Nomenclature


Accepted name:
N4-bis(aminopropyl)spermidine synthase
Systematic name:
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase [N4-bis(aminopropyl)spermidine synthesizing]



The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N4-bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. When spermine is used as substrate, the enzyme forms N4-aminopropylspermine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Okada, K., Hidese, R., Fukuda, W., Niitsu, M., Takao, K., Horai, Y., Umezawa, N., Higuchi, T., Oshima, T., Yoshikawa, Y., Imanaka, T., Fujiwara, S.
    Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.
    J. Bacteriol. 196 : 1866-1876 (2014). [PMID: 24610711]

[EC created 2014]