EC 2.5.1.127 - Caldopentamine synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.127

Names

Accepted name:
caldopentamine synthase
Other name:
long-chain polyamine synthase [ambiguous]
Systematic name:
S-adenosyl 3-(methylsulfanyl)propylamine:norspermine 3-aminopropyltransferase

Reaction

Comments:

The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Knott, J. M.
    Biosynthesis of long-chain polyamines by crenarchaeal polyamine synthases from Hyperthermus butylicus and Pyrobaculum aerophilum.
    FEBS Lett. 583 : 3519-3524 (2009). [PMID: 19822146]

[EC 2.5.1.127 created 2014]