EC 2.5.1.124 - 6-linalyl-2-O,3-dimethylflaviolin synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.124

Names

Accepted name:
6-linalyl-2-O,3-dimethylflaviolin synthase
Other names:
Fur7 [ambiguous]
6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase
Systematic name:
geranyl diphosphate:2-O-methyl-3-methylflaviolin geranyltransferase (6-linalyl-2-O,3-dimethylflaviolin-forming)

Reaction

Comments:

The enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin D in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 6-linalyl-2-O,3-dimethylflaviolin and 7-O-geranyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.125, 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase) in a 10:1 ratio.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kumano, T., Tomita, T., Nishiyama, M., Kuzuyama, T.
    Functional characterization of the promiscuous prenyltransferase responsible for furaquinocin biosynthesis: identification of a physiological polyketide substrate and its prenylated reaction products.
    J. Biol. Chem. 285 : 39663-39671 (2010). [PMID: 20937800]

[EC 2.5.1.124 created 2014]