EC 2.5.1.120 - Aminodeoxyfutalosine synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.120

Names

Accepted name:
aminodeoxyfutalosine synthase
Other names:
MqnE
AFL synthase
aminofutalosine synthase
Systematic name:
S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (HCO3--hydrolysing, 6-amino-6-deoxyfutalosine-forming)

Reaction

Comments:

This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102573
UniProtKB/Swiss-Prot:

References

  1. Mahanta, N., Fedoseyenko, D., Dairi, T., Begley, T. P.
    Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme.
    J. Am. Chem. Soc. 135: 15318-15321 (2013). [PMID: 24083939]

[EC 2.5.1.120 created 2014]