EC 2.5.1.119 - β-(isoxazolin-5-on-4-yl)-L-alanine synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.119

Names

Accepted name:
β-(isoxazolin-5-on-4-yl)-L-alanine synthase
Systematic name:
O3-acetyl-L-serine:isoxazolin-5-one 4-(2-amino-2-carboxyethyl)transferase

Reaction

Comments:

3-(5-Oxoisoxazolin-4-yl)-L-alanine is an antifungal antibiotic produced by the bacterium Streptomyces platensis. The enzymes from the plants Lathyrus odoratus (sweet pea), L. sativus (grass pea) and Citrullus vulgaris (watermelon) that catalyse EC 2.5.1.118 (β-(isoxazolin-5-on-2-yl)-L-alanine synthase) also catalyse this reaction in vitro, but not in vivo. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, β-pyrazolylalanine synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Ikegami, F., Kamiya, M., Kuo, Y. H., Lambein, F., Murakoshi, I.
    Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.
    Biol. Pharm. Bull. 19 : 1214-1215 (1996). [PMID: 8889043]

[EC 2.5.1.119 created 2014]