EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.118 - β-(isoxazolin-5-on-2-yl)-L-alanine synthase
IntEnz Enzyme Nomenclature
EC 2.5.1.118
Names
Reaction
-
22112 [IUBMB]isoxazolin-5-oneName origin: UniProt - CHECKED (C)Formula: C3H3NO2
Charge: 0ChEBI compound status: CHECKED (C)O-acetyl-L-serineName origin: UniProt - CHECKED (C)Formula: C5H9NO4
Charge: 0ChEBI compound status: CHECKED (C)=3-(5-oxoisoxazolin-2-yl)-L-alanineName origin: UniProt - CHECKED (C)Formula: C6H8N2O4
Charge: 0ChEBI compound status: CHECKED (C)acetateName origin: UniProt - CHECKED (C)Formula: C2H3O2
Charge: -1ChEBI compound status: CHECKED (C)
Comments:
The enzyme from the plants Lathyrus odoratus (sweet pea) and L. sativus (grass pea) also forms 3-(5-oxoisoxazolin-4-yl)-L-alanine in vitro (cf. EC 2.5.1.119). However, only 3-(5-oxoisoxazolin-2-yl)-L-alanine is formed in vivo. 3-(5-oxoisoxazolin-2-yl)-L-alanine is the biosynthetic precursor of the neurotoxin N3-oxalyl-L-2,3-diaminopropanoic acid, the cause of lathyrism. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, β-pyrazolylalanine synthase.
Links to other databases
References
-
Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.Biol. Pharm. Bull. 19: 1214-1215 (1996). [PMID: 8889043]
[EC 2.5.1.118 created 2014]