IntEnz

EC 2.5.1.118 - β-(isoxazolin-5-on-2-yl)-L-alanine synthase

IntEnz Enzyme Nomenclature
EC 2.5.1.118

Names

Reaction

• 22112 [IUBMB]
  isoxazolin-5-one

  isoxazolin-5-one

  Name origin: UniProt - CHECKED (C)

  CHEBI:76851

  Formula: C3H3NO2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  O-acetyl-L-serine

  O-acetyl-L-serine

  Name origin: UniProt - CHECKED (C)

  CHEBI:58340

  Formula: C5H9NO4
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  3-(5-oxoisoxazolin-2-yl)-L-alanine

  3-(5-oxoisoxazolin-2-yl)-L-alanine

  Name origin: UniProt - CHECKED (C)

  CHEBI:76855

  Formula: C6H8N2O4
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  acetate

  acetate

  Name origin: UniProt - CHECKED (C)

  CHEBI:30089

  Formula: C2H3O2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme from the plants Lathyrus odoratus (sweet pea) and L. sativus (grass pea) also forms 3-(5-oxoisoxazolin-4-yl)-L-alanine in vitro (cf. EC 2.5.1.119). However, only 3-(5-oxoisoxazolin-2-yl)-L-alanine is formed in vivo. 3-(5-oxoisoxazolin-2-yl)-L-alanine is the biosynthetic precursor of the neurotoxin N³-oxalyl-L-2,3-diaminopropanoic acid, the cause of lathyrism. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, β-pyrazolylalanine synthase.

Links to other databases

References

1. Ikegami, F., Kamiya, M., Kuo, Y. H., Lambein, F., Murakoshi, I.
   Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species.
   Biol. Pharm. Bull. 19: 1214-1215 (1996). [PMID: 8889043]

[EC 2.5.1.118 created 2014]