EC 2.5.1.116 - Homogentisate geranylgeranyltransferase

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IntEnz Enzyme Nomenclature
EC 2.5.1.116

Names

Accepted name:
homogentisate geranylgeranyltransferase
Other names:
HGGT
slr1736 (gene name)
Systematic name:
geranylgeranyl diphosphate:homogentisate geranylgeranyltransferase

Reaction

Cofactor

Comments:

Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102551
UniProtKB/Swiss-Prot:

References

  1. Collakova, E., DellaPenna, D.
    Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
    Plant Physiol. 127 : 1113-1124 (2001). [PMID: 11706191]
  2. Cahoon, E. B., Hall, S. E., Ripp, K. G., Ganzke, T. S., Hitz, W. D., Coughlan, S. J.
    Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content.
    Nat. Biotechnol. 21 : 1082-1087 (2003). [PMID: 12897790]
  3. Yang, W., Cahoon, R. E., Hunter, S. C., Zhang, C., Han, J., Borgschulte, T., Cahoon, E. B.
    Vitamin E biosynthesis: functional characterization of the monocot homogentisate geranylgeranyl transferase.
    Plant J. 65 : 206-217 (2011). [PMID: 21223386]

[EC 2.5.1.116 created 2014]