EC - Homogentisate geranylgeranyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
homogentisate geranylgeranyltransferase
Other names:
slr1736 (gene name)
Systematic name:
geranylgeranyl diphosphate:homogentisate geranylgeranyltransferase




Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102551


  1. Collakova, E., DellaPenna, D.
    Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
    Plant Physiol. 127 : 1113-1124 (2001). [PMID: 11706191]
  2. Cahoon, E. B., Hall, S. E., Ripp, K. G., Ganzke, T. S., Hitz, W. D., Coughlan, S. J.
    Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content.
    Nat. Biotechnol. 21 : 1082-1087 (2003). [PMID: 12897790]
  3. Yang, W., Cahoon, R. E., Hunter, S. C., Zhang, C., Han, J., Borgschulte, T., Cahoon, E. B.
    Vitamin E biosynthesis: functional characterization of the monocot homogentisate geranylgeranyl transferase.
    Plant J. 65 : 206-217 (2011). [PMID: 21223386]

[EC created 2014]