EC - 4-hydroxyphenylpyruvate 3-dimethylallyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxyphenylpyruvate 3-dimethylallyltransferase
Other names:
4HPP dimethylallyltransferase
Systematic name:
dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase



The enzyme is involved in the biosynthesis of the 3-dimethylallyl-4-hydroxyphenylpyruvate moiety of the aminocoumarin antibiotics clorobiocin and novobiocin [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Pojer, F., Wemakor, E., Kammerer, B., Chen, H., Walsh, C. T., Li, S. M., Heide, L.
    CloQ, a prenyltransferase involved in clorobiocin biosynthesis.
    Proc. Natl. Acad. Sci. U.S.A. 100: 2316-2321 (2003). [PMID: 12618544]
  2. Keller, S., Pojer, F., Heide, L., Lawson, D. M.
    Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62: 1153-1155 (2006). [PMID: 17077503]
  3. Metzger, U., Keller, S., Stevenson, C. E., Heide, L., Lawson, D. M.
    Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway.
    J. Mol. Biol. 404: 611-626 (2010). [PMID: 20946900]
  4. Ozaki, T., Mishima, S., Nishiyama, M., Kuzuyama, T.
    NovQ is a prenyltransferase capable of catalyzing the addition of a dimethylallyl group to both phenylpropanoids and flavonoids.
    J. Antibiot. 62: 385-392 (2009). [PMID: 19557032]

[EC created 2013]