EC 2.5.1.106 - Tryprostatin B synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.106

Names

Accepted name:
tryprostatin B synthase
Other names:
ftmPT1 (gene name)
brevianamide F prenyltransferase [ambiguous]
Systematic name:
dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase

Reaction

Comments:

The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Grundmann, A., Li, S. M.
    Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus.
    Microbiology (Reading, Engl.) 151 : 2199-2207 (2005). [PMID: 16000710]
  2. Wollinsky, B., Ludwig, L., Xie, X., Li, S. M.
    Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1.
    Org. Biomol. Chem. 10 : 9262-9270 (2012). [PMID: 23090579]

[EC 2.5.1.106 created 2013]