EC 2.5.1.101 - N,N'-diacetyllegionaminate synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.101

Names

Accepted name:
N,N'-diacetyllegionaminate synthase
Other names:
neuB (gene name)
legI (gene name)
Systematic name:
phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-α-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase

Reaction

Cofactor

Comments:

Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.

Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Glaze, P. A., Watson, D. C., Young, N. M., Tanner, M. E.
    Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
    Biochemistry 47 : 3272-3282 (2008). [PMID: 18275154]
  2. Schoenhofen, I. C., Vinogradov, E., Whitfield, D. M., Brisson, J. R., Logan, S. M.
    The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
    Glycobiology 19 : 715-725 (2009). [PMID: 19282391]

[EC 2.5.1.101 created 2012]