EC - (2E,6E)-farnesyl diphosphate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
(2E,6E)-farnesyl diphosphate synthase
Other names:
farnesyl pyrophosphate synthetase
farnesyl-diphosphate synthase
farnesylpyrophosphate synthetase
geranyl transferase I
FPP synthetase
Systematic name:
geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase



Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00407
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004337
CAS Registry Number: 37277-79-5
UniProtKB/Swiss-Prot: (111) [show] [UniProt]


  1. Lynen, F., Agranoff, B.W., Eggerer, H., Henning, V. and Möslein, E.M.
    Zur Biosynthese der Terpene. VI. γ,γ-Dimethyl-allyl-pyrophosphat und Geranyl-pyrophosphat, biologische Vorstufen des Squalens.
    Angew. Chem. 71 : 657-663 (1959).
  2. Ogura, K., Nishino, T. and Seto, S.
    The purification of prenyltransferase and isopentenyl pyrophosphate isomerase of pumpkin fruit and their some properties.
    J. Biochem. (Tokyo) 64 : 197-203 (1968). [PMID: 4303505]
  3. Reed, B.C. and Rilling, H.
    Crystallization and partial characterization of prenyltransferase from avian liver.
    Biochemistry 64 : 197-203 (1968). [PMID: 1109590]
  4. Takahashi, I. and Ogura, K.
    Farnesyl pyrophosphate synthetase from Bacillus subtilis.
    J. Biochem. (Tokyo) 89 : 1581-1587 (1981). [PMID: 6792191]
  5. Takahashi, I. and Ogura, K.
    Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase.
    J. Biochem. (Tokyo) 92 : 1527-1537 (1982). [PMID: 6818223]

[EC created 1972, modified 2010]