EC 2 - Transferases
EC 2.5 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1 - Transferring alkyl or aryl groups, other than methyl groups
EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.5.1.10
Names
Accepted name:
(2E,6E)-farnesyl diphosphate synthase
Other
names:
farnesyl pyrophosphate synthetase
farnesyl-diphosphate synthase
farnesylpyrophosphate synthetase
geranyl transferase I
prenyltransferase
FPP synthetase
geranyltranstransferase
farnesyl-diphosphate synthase
farnesylpyrophosphate synthetase
geranyl transferase I
prenyltransferase
FPP synthetase
geranyltranstransferase
Systematic name:
geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
Reaction
- geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Comments:
Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00407
Gene Ontology:
GO:0004337
CAS Registry Number:
37277-79-5
References
-
Zur Biosynthese der Terpene. VI. γ,γ-Dimethyl-allyl-pyrophosphat und Geranyl-pyrophosphat, biologische Vorstufen des Squalens.Angew. Chem. 71 : 657-663 (1959).
-
The purification of prenyltransferase and isopentenyl pyrophosphate isomerase of pumpkin fruit and their some properties.J. Biochem. (Tokyo) 64 : 197-203 (1968). [PMID: 4303505]
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Crystallization and partial characterization of prenyltransferase from avian liver.Biochemistry 64 : 197-203 (1968). [PMID: 1109590]
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Farnesyl pyrophosphate synthetase from Bacillus subtilis.J. Biochem. (Tokyo) 89 : 1581-1587 (1981). [PMID: 6792191]
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Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase.J. Biochem. (Tokyo) 92 : 1527-1537 (1982). [PMID: 6818223]
[EC 2.5.1.10 created 1972, modified 2010]