EC 2.4.99.8 - α-N-acetylneuraminate α-2,8-sialyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.99.8

Names

Accepted name:
α-N-acetylneuraminate α-2,8-sialyltransferase
Other names:
α-2,8-sialyltransferase
CMP-NeuAc:LM1(α2-8) sialyltranferase
GD3 synthase
SAT-2
cytidine monophosphoacetylneuraminate-ganglioside GM3
ganglioside GD3 synthase
ganglioside GD3 synthetase sialyltransferase
CMP-N-acetylneuraminate:α-N-acetylneuraminyl-2,3-β-D-galactoside α-2,8-N-acetylneuraminyltransferase
Systematic name:
CMP-N-acetylneuraminate:α-N-acetylneuraminyl-(2→3)-β-D-galactoside α-(2→8)-N-acetylneuraminyltransferase

Reaction

Comments:

Gangliosides act as acceptors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003828
CAS Registry Number: 67339-00-8
UniProtKB/Swiss-Prot:

References

  1. Eppler, M.C., Morré, J.D. and Keenan, T.W.
    Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.
    Biochim. Biophys. Acta 619 : 332-343 (1980). [PMID: 7407217]
  2. Higashi, H., Basu, M. and Basu, S.
    Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
    J. Biol. Chem. 260 : 824-828 (1985). [PMID: 3838172]
  3. McCoy, R.D., Vimr, E.R. and Troy, F.A.
    CMP-NeuNAc:poly-α-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.
    J. Biol. Chem. 260 : 12695-12699 (1985). [PMID: 4044605]
  4. Yohe, H.C. and Yu, R.K.
    In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.
    J. Biol. Chem. 255 : 608-613 (1980). [PMID: 6766128]

[EC 2.4.99.8 created 1984, modified 1986]