EC 2.4.99.20 - 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

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IntEnz Enzyme Nomenclature
EC 2.4.99.20

Names

Accepted name:
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
Other names:
diphosphopyridine nucleosidase [ambiguous]
CD38 (gene name)
BST1 (gene name)
Systematic name:
NADP+:nicotinate ADP-ribosyltransferase

Reaction

Comments:

This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Chini, E. N., Chini, C. C., Kato, I., Takasawa, S., Okamoto, H.
    CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
    Biochem. J. 362: 125-130 (2002). [PMID: 11829748]
  2. Moreschi, I., Bruzzone, S., Melone, L., De Flora, A., Zocchi, E.
    NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
    Biochem. Biophys. Res. Commun. 345: 573-580 (2006). [PMID: 16690024]

[EC 2.4.99.20 created 2014]