EC 2.4.99.15 - (Kdo)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase

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IntEnz Enzyme Nomenclature
EC 2.4.99.15

Names

Accepted name:
(Kdo)3-lipid IVA (2-4) 3-deoxy-D-manno-octulosonic acid transferase
Other names:
Kdo transferase [ambiguous]
waaA
kdtA
3-deoxy-D-manno-oct-2-ulosonic acid transferase
3-deoxy-manno-octulosonic acid transferase
Systematic name:
CMP-3-deoxy-D-manno-octulosonate:(KDO)3-lipid IVA 3-deoxy-D-manno-octulosonate transferase ((2→4) glycosidic bond-forming)

Reactions

Comments:

The enzyme from Chlamydia psittaci transfers four KDO residues to lipid A, forming a branched tetrasaccharide with the structure α-KDO-(2,8)-[α-KDO-(2,4)]-α-KDO-(2,4)-α-KDO (cf. EC 2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase], EC 2.4.99.13 [(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase], and EC 2.4.99.14 [(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase]).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043842
UniProtKB/Swiss-Prot:

References

  1. Brabetz, W., Lindner, B., Brade, H.
    Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12.
    Eur. J. Biochem. 267 : 5458-5465 (2000). [PMID: 10951204]
  2. Holst, O., Bock, K., Brade, L., Brade, H.
    The structures of oligosaccharide bisphosphates isolated from the lipopolysaccharide of a recombinant Escherichia coli strain expressing the gene gseA [3-deoxy-D-manno-octulopyranosonic acid (Kdo) transferase] of Chlamydia psittaci 6BC.
    Eur. J. Biochem. 229 : 194-200 (1995). [PMID: 7744029]

[EC 2.4.99.15 created 2010, modified 2011 ]