EC 2.4.99.14 - (Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.4.99.14

Names

Accepted name:
(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase
Other names:
Kdo transferase [ambiguous]
waaA
kdtA
3-deoxy-D-manno-oct-2-ulosonic acid transferase
3-deoxy-manno-octulosonic acid transferase
Systematic name:
CMP-3-deoxy-D-manno-octulosonate:(KDO)2-lipid IVA 3-deoxy-D-manno-octulosonate transferase ((2→8) glycosidic bond-forming)

Reaction

Comments:

The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-octulosonate residues and generate genus-specific epitopes.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lobau, S., Mamat, U., Brabetz, W., Brade, H.
    Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183.
    Mol. Microbiol. 18: 391-399 (1995). [PMID: 8748024]
  2. Mamat, U., Baumann, M., Schmidt, G., Brade, H.
    The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology.
    Mol. Microbiol. 10: 935-941 (1993). [PMID: 7523826]
  3. Belunis, C. J., Mdluli, K. E., Raetz, C. R., Nano, F. E.
    A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope.
    J. Biol. Chem. 267: 18702-18707 (1992). [PMID: 1382060]

[EC 2.4.99.14 created 2010, modified 2011]