EC 2.4.99.13 - (Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
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IntEnz Enzyme Nomenclature
EC 2.4.99.13
Names
Accepted name:
(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
Other
names:
waaA
kdtA
Kdo transferase
3-deoxy-D-manno-oct-2-ulosonic acid transferase
3-deoxy-manno-octulosonic acid transferase
kdtA
Kdo transferase
3-deoxy-D-manno-oct-2-ulosonic acid transferase
3-deoxy-manno-octulosonic acid transferase
Systematic name:
CMP-3-deoxy-β-D-manno-oct-2-ulosonate:α-Kdo-(2→6)-[lipid IVA] 3-deoxy-D-manno-oct-2-ulosonate transferase (configuration-inverting)
Reactions
- (1) alpha-Kdo-(2right6)-lipid IVA + CMP-beta-Kdo = alpha-Kdo-(2right4)-alpha-Kdo-(2right6)-lipid IVA + CMP
- (2) CMP-beta-Kdo + an alpha-Kdo-(2right6)-[lipid IVA] = CMP + an alpha-Kdo-(2right4)-alpha-Kdo-(2right6)-[lipid IVA]
Comments:
The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [2].
Links to other databases
Gene Ontology:
GO:0043842
References
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Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli.J. Biol. Chem. 267 : 9988-9997 (1992). [PMID: 1577828]
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Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183.Mol. Microbiol. 18 : 391-399 (1995). [PMID: 8748024]
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Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis.Proc Natl Acad Sci U S A 109 : 6253-6258 (2012). [PMID: 22474366]
[EC 2.4.99.13 created 2010, modified 2011]