EC 2.4.2.7 - Adenine phosphoribosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.2.7

Names

Accepted name:
adenine phosphoribosyltransferase
Other names:
AMP pyrophosphorylase
AMP-pyrophosphate phosphoribosyltransferase
APRT
adenine phosphoribosylpyrophosphate transferase
adenosine phosphoribosyltransferase
adenylate pyrophosphorylase
adenylic pyrophosphorylase
transphosphoribosidase
Systematic name:
AMP:diphosphate phospho-D-ribosyltransferase

Reaction

Comments:

5-Amino-4-imidazolecarboxamide can replace adenine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00096
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003999
CAS Registry Number: 9027-80-9
UniProtKB/Swiss-Prot: (646) [show] [UniProt]

References

  1. Flaks, J.G., Erwin, M.J. and Buchanan, J.M.
    Biosynthesis of the purines. XVI. The synthesis of adenosine 5'-phosphate and 5-amino-4-imidazolecarboxamide ribotide by a nucleotide pyrophosphorylase.
    J. Biol. Chem. 228 : 201-213 (1957).
  2. Kornberg, A., Lieberman, I. and Simms, E.S.
    Enzymatic synthesis of purine nucleotides.
    J. Biol. Chem. 215 : 417-427 (1955).
  3. Lukens, L.N. and Herrington, K.A.
    Enzymic formation of 6-mercaptopurine ribotide.
    Biochim. Biophys. Acta 24 : 432-433 (1957).

[EC 2.4.2.7 created 1961]