EC 2.4.2.52 - Triphosphoribosyl-dephospho-CoA synthase

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IntEnz Enzyme Nomenclature
EC 2.4.2.52

Names

Accepted name:
triphosphoribosyl-dephospho-CoA synthase
Other names:
2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase
ATP:dephospho-CoA 5-triphosphoribosyl transferase
CitG
ATP:dephospho-CoA 5'-triphosphoribosyl transferase
MdcB
ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase
MadG
Systematic name:
ATP:3'-dephospho-CoA 5-triphosphoribosyltransferase

Reaction

Comments:

ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new α (1''→2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (γ-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046917
CAS Registry Number: 313345-38-9
UniProtKB/Swiss-Prot: (76) [show] [UniProt]

References

  1. Schneider, K., Dimroth, P. and Bott, M.
    Biosynthesis of the prosthetic group of citrate lyase.
    Biochemistry 39 : 9438-9450 (2000). [PMID: 10924139]
  2. Schneider, K., Dimroth, P. and Bott, M.
    Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group.
    FEBS Lett. 483 : 165-168 (2000). [PMID: 11042274]
  3. Schneider, K., Kastner, C.N., Meyer, M., Wessel, M., Dimroth, P. and Bott, M.
    Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group.
    J. Bacteriol. 184 : 2439-2446 (2002). [PMID: 11948157]
  4. Hoenke, S., Wild, M.R. and Dimroth, P.
    Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase.
    Biochemistry 39 : 13223-13232 (2000). [PMID: 11052675]

[EC 2.4.2.52 created 2002 as EC 2.7.8.25, modified 2008, transferred 2013 to EC 2.4.2.52]