EC 2.4.2.19 - Nicotinate-nucleotide diphosphorylase (carboxylating)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.4.2.19
Names
Accepted name:
nicotinate-nucleotide diphosphorylase (carboxylating)
Other
names:
NAD pyrophosphorylase
QAPRTase
nicotinate mononucleotide pyrophosphorylase (carboxylating)
quinolinate phosphoribosyltransferase (decarboxylating)
quinolinic acid phosphoribosyltransferase
quinolinic phosphoribosyltransferase
nicotinate-nucleotide pyrophosphorylase (carboxylating)
nicotinate-nucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
QAPRTase
nicotinate mononucleotide pyrophosphorylase (carboxylating)
quinolinate phosphoribosyltransferase (decarboxylating)
quinolinic acid phosphoribosyltransferase
quinolinic phosphoribosyltransferase
nicotinate-nucleotide pyrophosphorylase (carboxylating)
nicotinate-nucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
Systematic name:
β-nicotinate-D-ribonucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
Reaction
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12733 [IUBMB]+CO2Name origin: UniProt - CHECKED (C)Formula: CO2
Charge: 0ChEBI compound status: CHECKED (C)+diphosphateName origin: UniProt - CHECKED (C)Formula: HO7P2
Charge: -3ChEBI compound status: CHECKED (C)nicotinate β-D-ribonucleotideName origin: UniProt - CHECKED (C)Formula: C11H12NO9P
Charge: -2ChEBI compound status: CHECKED (C)=+5-phospho-α-D-ribose 1-diphosphateName origin: UniProt - CHECKED (C)Formula: C5H8O14P3
Charge: -5ChEBI compound status: CHECKED (C)2+H+Name origin: UniProt - CHECKED (C)Formula: H
Charge: 1ChEBI compound status: CHECKED (C)
Comments:
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0004514
CAS Registry Number:
37277-74-0
References
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The enzymatic conversion of quinolinate to nicotinic acid mononucleotide in mammalian liver.J. Biol. Chem. 239: 1208-1214 (1964).
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Crystalline quinolinate phosphoribosyltransferase.J. Biol. Chem. 240: 4107-4108 (1965). [PMID: 5320648]
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Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid.Plant Physiol. 141: 851-857 (2006). [PMID: 16698895]
[EC 2.4.2.19 created 1972]