EC 2.4.2.19 - Nicotinate-nucleotide diphosphorylase (carboxylating)
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.4.2.19
Names
Accepted name:
nicotinate-nucleotide diphosphorylase (carboxylating)
Other
names:
NAD pyrophosphorylase
QAPRTase
nicotinate mononucleotide pyrophosphorylase (carboxylating)
quinolinate phosphoribosyltransferase (decarboxylating)
quinolinic acid phosphoribosyltransferase
quinolinic phosphoribosyltransferase
nicotinate-nucleotide pyrophosphorylase (carboxylating)
nicotinate-nucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
QAPRTase
nicotinate mononucleotide pyrophosphorylase (carboxylating)
quinolinate phosphoribosyltransferase (decarboxylating)
quinolinic acid phosphoribosyltransferase
quinolinic phosphoribosyltransferase
nicotinate-nucleotide pyrophosphorylase (carboxylating)
nicotinate-nucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
Systematic name:
β-nicotinate-D-ribonucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
Reaction
- beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
Comments:
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0004514
CAS Registry Number:
37277-74-0
References
-
The enzymatic conversion of quinolinate to nicotinic acid mononucleotide in mammalian liver.J. Biol. Chem. 239 : 1208-1214 (1964).
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Crystalline quinolinate phosphoribosyltransferase.J. Biol. Chem. 240 : 4107-4108 (1965). [PMID: 5320648]
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Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid.Plant Physiol. 141 : 851-857 (2006). [PMID: 16698895]
[EC 2.4.2.19 created 1972]