EC 18.104.22.168 - Nicotinate-nucleotide diphosphorylase (carboxylating)
IntEnz Enzyme Nomenclature
nicotinate mononucleotide pyrophosphorylase (carboxylating)
quinolinate phosphoribosyltransferase (decarboxylating)
quinolinic acid phosphoribosyltransferase
nicotinate-nucleotide pyrophosphorylase (carboxylating)
nicotinate-nucleotide:diphosphate phospho-α-D-ribosyltransferase (carboxylating)
- beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes .
Links to other databases
The enzymatic conversion of quinolinate to nicotinic acid mononucleotide in mammalian liver.J. Biol. Chem. 239 : 1208-1214 (1964).
Crystalline quinolinate phosphoribosyltransferase.J. Biol. Chem. 240 : 4107-4108 (1965). [PMID: 5320648]
Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid.Plant Physiol. 141 : 851-857 (2006). [PMID: 16698895]
[EC 22.214.171.124 created 1972]