EC - Orotate phosphoribosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
orotate phosphoribosyltransferase
Other names:
orotate phosphoribosyl pyrophosphate transferase
orotic acid phosphoribosyltransferase
orotidine 5'-monophosphate pyrophosphorylase
orotidine monophosphate pyrophosphorylase
orotidine phosphoribosyltransferase
orotidine-5'-phosphate pyrophosphorylase
orotidylate phosphoribosyltransferase
orotidylate pyrophosphorylase
orotidylic acid phosphorylase
orotidylic acid pyrophosphorylase
orotidylic phosphorylase
orotidylic pyrophosphorylase
orotidine-5'-phosphate diphosphorylase
Systematic name:
orotidine-5'-phosphate:diphosphate phospho-α-D-ribosyl-transferase



The enzyme from higher eukaryotes also catalyses the reaction listed as EC, orotidine-5'-phosphate decarboxylase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00096
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004588
CAS Registry Number: 9030-25-5
UniProtKB/Swiss-Prot: (471) [show] [UniProt]


  1. Jones, M.E., Kavipurapu, P.R. and Traut, T.W.
    Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell).
    Methods Enzymol. 51: 155-167 (1978). [PMID: 692383]
  2. Lieberman, I., Kornberg, A. and Simms, E.S.
    Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5'-phosphate and uridine-5'-phosphate.
    J. Biol. Chem. 215: 403-415 (1955). [PMID: 14392174]
  3. McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E.
    Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase.
    Biochemistry 19: 4699-4706 (1980). [PMID: 6893554]

[EC created 1961, modified 1986]