EC 2.4.1.68 - Glycoprotein 6-α-L-fucosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.68

Names

Accepted name:
glycoprotein 6-α-L-fucosyltransferase
Other names:
GDP-L-Fuc:N-acetyl-β-D-glucosaminide α(1→6)fucosyltransferase
GDP-L-fucose-glycoprotein fucosyltransferase
glycoprotein fucosyltransferase
guanosine diphosphofucose-glycoprotein fucosyltransferase
GDP-fucose—glycoprotein fucosyltransferase
FucT
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 6-α-L-fucosyltransferase
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 6-α-L-fucosyltransferase
Systematic name:
GDP-β-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 6-α-L-fucosyltransferase

Reaction

Comments:

This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3α-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-β-L-fucose to form an α1,6-linkage rather than an α1,3-linkage.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008424
CAS Registry Number: 9033-08-3
UniProtKB/Swiss-Prot: (14) [show] [UniProt]

References

  1. Longmore, G.D. and Schachter, H.
    Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-β-D-glucoside (FUC→Asn-linked GlcNAc) 6-α-L-fucosyltransferase in a Golgi-rich fraction from porcine liver.
    Carbohydr. Res. 100 : 365-392 (1982). [PMID: 7083256]
  2. Voynow, J.A., Scanlin, T.F. and Glick, M.C.
    A quantitative method for GDP-L-Fuc:N-acetyl-β-D-glucosaminide α1→6fucosyltransferase activity with lectin affinity chromatography.
    Anal. Biochem. 168 : 367-373 (1988). [PMID: 3364733]
  3. Uozumi, N., Yanagidani, S., Miyoshi, E., Ihara, Y., Sakuma, T., Gao, C.-X., Teshima, T., Fujii, S., Shiba, T. and Taniguchi, N.
    Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-β-D-glucosaminide α1→6fucosyltransferase.
    J. Biol. Chem. 271 : 27810-27817 (1996). [PMID: 8910378]

[EC 2.4.1.68 created 1972, modified 2002]