EC 2.4.1.52 - Poly(glycerol-phosphate) α-glucosyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.4.1.52

Names

Accepted name:
poly(glycerol-phosphate) α-glucosyltransferase
Other names:
UDP glucose-poly(glycerol-phosphate) α-glucosyltransferase
uridine diphosphoglucose-poly(glycerol-phosphate) α-glucosyltransferase
tagE (gene name)
UDP-glucose:poly(glycerol-phosphate) α-D-glucosyltransferase
Systematic name:
UDP-α-D-glucose:4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol α-D-glucosyltransferase (configuration-retaining)

Reaction

Comments:

Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme, isolated from Bacillus subtilis 168, adds an α-D-glucose to the free OH groups of the glycerol units. The enzyme has a strong preference for UDP-α-glucose as the sugar donor. It has no activity with poly(ribitol phosphate).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047265
CAS Registry Number: 37277-60-4
UniProtKB/Swiss-Prot:

References

  1. Glaser, L. and Burger, M.M.
    The synthesis of teichoic acids. 3. Glucosylation of polyglycerophosphate.
    J. Biol. Chem. 239: 3187-3191 (1964). [PMID: 14245359]
  2. Allison, S. E., D'Elia, M. A., Arar, S., Monteiro, M. A., Brown, E. D.
    Studies of the genetics, function, and kinetic mechanism of TagE, the wall teichoic acid glycosyltransferase in Bacillus subtilis 168.
    J. Biol. Chem. 286: 23708-23716 (2011). [PMID: 21558268]

[EC 2.4.1.52 created 1972, modified 2017]