IntEnz

EC 2.4.1.41 - Polypeptide N-acetylgalactosaminyltransferase

IntEnz Enzyme Nomenclature
EC 2.4.1.41

Names

Reactions

• 23956 [IUBMB]
  L-seryl-[protein]

  L-seryl-[protein]

  GENERIC:9863

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  UDP-N-acetyl-α-D-galactosamine

  UDP-N-acetyl-alpha-D-galactosamine

  Name origin: UniProt - CHECKED (C)

  CHEBI:67138

  Formula: C17H25N3O17P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  =

  3-O-[N-acetyl-α-D-galactosaminyl]-L-seryl-[protein]

  3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]

  GENERIC:12788

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  N-acetyl-α-D-galactosaminyl-L-serine residue N-acetyl-alpha-D-galactosaminyl-L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:53604 Formula: C11H18N2O7 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  UDP

  UDP

  Name origin: UniProt - CHECKED (C)

  CHEBI:58223

  Formula: C9H11N2O12P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  
• 52424 [IUBMB]
  L-threonyl-[protein]

  L-threonyl-[protein]

  GENERIC:11060

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  L-threonine residue L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:30013 Formula: C4H7NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  UDP-N-acetyl-α-D-galactosamine

  UDP-N-acetyl-alpha-D-galactosamine

  Name origin: UniProt - CHECKED (C)

  CHEBI:67138

  Formula: C17H25N3O17P2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  =

  3-O-[N-acetyl-α-D-galactosaminyl]-L-threonyl-[protein]

  3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]

  GENERIC:11689

  Is ROOT: no
  ROOT compound: GENERIC:9624

  Number of residues: 1

  N-acetyl-α-D-galactosaminyl-L-threonine residue N-acetyl-alpha-D-galactosaminyl-L-threonine residue Name origin: UniProt - CHECKED (C) CHEBI:87075 Formula: C12H20N2O7 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  UDP

  UDP

  Name origin: UniProt - CHECKED (C)

  CHEBI:58223

  Formula: C9H11N2O12P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

Cofactors

• Ca²⁺
• Mn²⁺

Comments:

Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, κ-casein, apofetuin and some other acceptors of high molecular mass.

Links to other databases

References

1. Sugiura, M., Kawasaki, T. and Yamashina, I.
   Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66.
   J. Biol. Chem. 257 : 9501-9507 (1982). [PMID: 6809738]
2. Takeuchi, M., Yoshikawa, M., Sasaki, R. and Chiba, H.
   Purification and characterization of UDP-N-acetylgalactosamine-κ-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow.
   Agric. Biol. Chem. 49 : 1059-1069 (1985).

[EC 2.4.1.41 created 1972, modified 1989]