EC 2.4.1.338 - Validoxylamine A glucosyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.4.1.338

Names

Accepted name:
validoxylamine A glucosyltransferase
Other names:
vldK (gene name)
valG (gene name)
Systematic name:
UDP-α-D-glucose:validoxylamine-A D-glucosyltransferase

Reaction

Comments:

The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Bai, L., Li, L., Xu, H., Minagawa, K., Yu, Y., Zhang, Y., Zhou, X., Floss, H. G., Mahmud, T., Deng, Z.
    Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.
    Chem. Biol. 13: 387-397 (2006). [PMID: 16632251]
  2. Xu, H., Minagawa, K., Bai, L., Deng, Z., Mahmud, T.
    Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A.
    J. Nat. Prod. 71: 1233-1236 (2008). [PMID: 18563934]

[EC 2.4.1.338 created 2016]