EC 2.4.1.335 - Dolichyl N-acetyl-α-D-glucosaminyl phosphate 3-β-D-2,3-diacetamido-2,3-dideoxy-β-D-glucuronosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.335

Names

Accepted name:
dolichyl N-acetyl-α-D-glucosaminyl phosphate 3-β-D-2,3-diacetamido-2,3-dideoxy-β-D-glucuronosyltransferase
Other names:
AglC
UDP-Glc-2,3-diNAcA glycosyltransferase
Systematic name:
UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronate:dolichyl N-acetyl-α-D-glucosaminyl-phosphate 3-β-D-2,3-diacetamido-2,3-dideoxy-β-D-glucuronosyltransferase

Reaction

Comments:

The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes; it is much shorter (C55-C60), it is α,ω-saturated and it may have additional unsaturated positions in the chain.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Larkin, A., Chang, M. M., Whitworth, G. E., Imperiali, B.
    Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis.
    Nat. Chem. Biol. 9: 367-373 (2013). [PMID: 23624439]

[EC 2.4.1.335 created 2015]