EC 2.4.1.33 - Mannuronan synthase

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IntEnz Enzyme Nomenclature
EC 2.4.1.33

Names

Accepted name:
mannuronan synthase
Other names:
mannuronosyl transferase
alginate synthase [incorrect]
alg8 (gene name)
alg44 (gene name)
GDP-D-mannuronate:alginate D-mannuronyltransferase
Systematic name:
GDP-α-D-mannuronate:mannuronan D-mannuronatetransferase

Reaction

Comments:

The enzyme catalyses the polymerization of β-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047643
CAS Registry Number: 37257-31-1
UniProtKB/Swiss-Prot:

References

  1. Lin, T.-Y. and Hassid, W.Z.
    Pathway of alginic acid synthesis in the marine brown alga, Fucus gardneri Silva.
    J. Biol. Chem. 241 : 5284-5297 (1966). [PMID: 5954796]
  2. Remminghorst, U., Rehm, B. H.
    In vitro alginate polymerization and the functional role of Alg8 in alginate production by Pseudomonas aeruginosa.
    Appl. Environ. Microbiol. 72 : 298-305 (2006). [PMID: 16391057]
  3. Oglesby, L. L., Jain, S., Ohman, D. E.
    Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate polymerization.
    Microbiology (Reading, Engl.) 154 : 1605-1615 (2008). [PMID: 18524915]

[EC 2.4.1.33 created 1972, modified 2015]