EC 2.4.1.327 - Aclacinomycin-T 2-deoxy-L-fucose transferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.4.1.327

Names

Accepted name:
aclacinomycin-T 2-deoxy-L-fucose transferase
Other name:
AknK
Systematic name:
dTDP-2-deoxy-β-L-fucose:7-(α-L-rhodosaminyl)aklavinone 2-deoxy-α-L-fucosyltransferase

Reactions

Comments:

The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lu, W., Leimkuhler, C., Oberthur, M., Kahne, D., Walsh, C. T.
    AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.
    Biochemistry 43: 4548-4558 (2004). [PMID: 15078101]

[EC 2.4.1.327 created 2014]