EC 2.4.1.326 - Aklavinone 7-L-rhodosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.326

Names

Accepted name:
aklavinone 7-L-rhodosaminyltransferase
Other names:
AknS/AknT
aklavinone 7-β-L-rhodosaminyltransferase
dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase
Systematic name:
dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase (configuration-inverting)

Reaction

Comments:

Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-β-L-fucose. Involved in the biosynthesis of other aclacinomycins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Lu, W., Leimkuhler, C., Gatto, G. J., Kruger, R. G., Oberthur, M., Kahne, D., Walsh, C. T.
    AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
    Chem. Biol. 12 : 527-534 (2005). [PMID: 15911373]
  2. Leimkuhler, C., Fridman, M., Lupoli, T., Walker, S., Walsh, C. T., Kahne, D.
    Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.
    J. Am. Chem. Soc. 129 : 10546-10550 (2007). [PMID: 17685523]

[EC 2.4.1.326 created 2014, modified 2015]