EC - Devancosaminyl-vancomycin vancosaminetransferase

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IntEnz Enzyme Nomenclature


Accepted name:
devancosaminyl-vancomycin vancosaminetransferase
Other names:
devancosamine-vancomycin TDP-vancosaminyltransferase
desvancosaminyl-vancomycin vancosaminetransferase
Systematic name:
dTDP-β-L-vancomycin:devancosaminyl-vancomycin β-L-vancosaminetransferase



The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Losey, H. C., Peczuh, M. W., Chen, Z., Eggert, U. S., Dong, S. D., Pelczer, I., Kahne, D., Walsh, C. T.
    Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.
    Biochemistry 40: 4745-4755 (2001). [PMID: 11294642]
  2. Mulichak, A. M., Lu, W., Losey, H. C., Walsh, C. T., Garavito, R. M.
    Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands.
    Biochemistry 43: 5170-5180 (2004). [PMID: 15122882]

[EC created 2014]