EC 2.4.1.322 - Devancosaminyl-vancomycin vancosaminetransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.322

Names

Accepted name:
devancosaminyl-vancomycin vancosaminetransferase
Other names:
GtfD
devancosamine-vancomycin TDP-vancosaminyltransferase
desvancosaminyl-vancomycin vancosaminetransferase
Systematic name:
dTDP-β-L-vancomycin:devancosaminyl-vancomycin β-L-vancosaminetransferase

Reaction

Comments:

The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Losey, H. C., Peczuh, M. W., Chen, Z., Eggert, U. S., Dong, S. D., Pelczer, I., Kahne, D., Walsh, C. T.
    Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.
    Biochemistry 40: 4745-4755 (2001). [PMID: 11294642]
  2. Mulichak, A. M., Lu, W., Losey, H. C., Walsh, C. T., Garavito, R. M.
    Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands.
    Biochemistry 43: 5170-5180 (2004). [PMID: 15122882]

[EC 2.4.1.322 created 2014]