EC 2.4.1.316 - Tylactone mycaminosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.316

Names

Accepted name:
tylactone mycaminosyltransferase
Other name:
tylM2 (gene name)
Systematic name:
dTDP-α-D-mycaminose:tylactone 5-O-β-D-mycaminosyltransferase

Reaction

Comments:

The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Gandecha, A. R., Large, S. L., Cundliffe, E.
    Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome.
    Gene 184: 197-203 (1997). [PMID: 9031628]
  2. Melancon, C. E., Takahashi, H., Liu, H. W.
    Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.
    J. Am. Chem. Soc. 126: 16726-16727 (2004). [PMID: 15612702]

[EC 2.4.1.316 created 2014]