EC - Protein O-mannose β-1,4-N-acetylglucosaminyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
protein O-mannose β-1,4-N-acetylglucosaminyltransferase
Other names:
GTDC2 (gene name)
Systematic name:
UDP-N-acetyl-α-D-glucosamine:α-D-mannosyl-threonyl-[protein] 4-β-N-acetyl-D-glucosaminyltransferase



The human protein is involved in the formation of a phosphorylated trisaccharide on a threonine residue of α-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (13) [show] [UniProt]


  1. Yoshida-Moriguchi, T., Willer, T., Anderson, M. E., Venzke, D., Whyte, T., Muntoni, F., Lee, H., Nelson, S. F., Yu, L., Campbell, K. P.
    SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
    Science 341 : 896-899 (2013). [PMID: 23929950]

[EC created 2013]