EC - N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Other name:
Systematic name:
dTDP-6-deoxy-β-L-mannose:N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-α-L-rhamnosyltransferase




Requires Mn2+ or Mg2+. Isolated from Mycobacterium smegmatis [1] and Mycobacterium tuberculosis [2]. The enzyme catalyses the addition of a rhamnosyl unit to N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol, completing the synthesis of the linkage unit that attaches the arabinogalactan moiety to the peptidoglycan moiety in Mycobacterial cell wall.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102096


  1. Mills, J. A., Motichka, K., Jucker, M., Wu, H. P., Uhlik, B. C., Stern, R. J., Scherman, M. S., Vissa, V. D., Pan, F., Kundu, M., Ma, Y. F., McNeil, M.
    Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability.
    J. Biol. Chem. 279: 43540-43546 (2004). [PMID: 15294902]
  2. Grzegorzewicz, A. E., Ma, Y., Jones, V., Crick, D., Liav, A., McNeil, M. R.
    Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL.
    Microbiology (Reading, Engl.) 154: 3724-3730 (2008). [PMID: 19047740]

[EC created 2012]