EC - 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
2-deoxystreptamine N-acetyl-D-glucosaminyltransferase
Other names:
btrM (gene name)
neoD (gene name)
kanF (gene name)
Systematic name:
UDP-N-acetyl-α-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase



Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose [2] (cf. EC, 2-deoxystreptamine glucosyltransferase), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-α-D-glucosamine [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102319


  1. Yokoyama, K., Yamamoto, Y., Kudo, F., Eguchi, T.
    Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.
    Chembiochem 9 : 865-869 (2008). [PMID: 18311744]
  2. Park, J. W., Park, S. R., Nepal, K. K., Han, A. R., Ban, Y. H., Yoo, Y. J., Kim, E. J., Kim, E. M., Kim, D., Sohng, J. K., Yoon, Y. J.
    Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
    Nat. Chem. Biol. 7 : 843-852 (2011). [PMID: 21983602]

[EC created 2012]