EC - 3-α-mycarosylerythronolide B desosaminyl transferase

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IntEnz Enzyme Nomenclature


Accepted name:
3-α-mycarosylerythronolide B desosaminyl transferase
Other names:
desosaminyl transferase EryCIII
Systematic name:
dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose:3-α-mycarosylerythronolide B 3-dimethylamino-3,4,6-trideoxy-β-D-glucosyltransferase



The enzyme is involved in erythromycin biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Yuan, Y., Chung, H. S., Leimkuhler, C., Walsh, C. T., Kahne, D., Walker, S.
    In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.
    J. Am. Chem. Soc. 127: 14128-14129 (2005). [PMID: 16218575]
  2. Lee, H. Y., Chung, H. S., Hang, C., Khosla, C., Walsh, C. T., Kahne, D., Walker, S.
    Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.
    J. Am. Chem. Soc. 126: 9924-9925 (2004). [PMID: 15303858]
  3. Moncrieffe, M. C., Fernandez, M. J., Spiteller, D., Matsumura, H., Gay, N. J., Luisi, B. F., Leadlay, P. F.
    Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII.
    J. Mol. Biol. 415: 92-101 (2012). [PMID: 22056329]

[EC created 2012, modified 2014]