EC 2.4.1.278 - 3-α-mycarosylerythronolide B desosaminyl transferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.278

Names

Accepted name:
3-α-mycarosylerythronolide B desosaminyl transferase
Other names:
EryCIII
desosaminyl transferase EryCIII
Systematic name:
dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose:3-α-mycarosylerythronolide B 3-dimethylamino-3,4,6-trideoxy-β-D-glucosyltransferase

Reaction

Comments:

The enzyme is involved in erythromycin biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Yuan, Y., Chung, H. S., Leimkuhler, C., Walsh, C. T., Kahne, D., Walker, S.
    In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.
    J. Am. Chem. Soc. 127: 14128-14129 (2005). [PMID: 16218575]
  2. Lee, H. Y., Chung, H. S., Hang, C., Khosla, C., Walsh, C. T., Kahne, D., Walker, S.
    Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.
    J. Am. Chem. Soc. 126: 9924-9925 (2004). [PMID: 15303858]
  3. Moncrieffe, M. C., Fernandez, M. J., Spiteller, D., Matsumura, H., Gay, N. J., Luisi, B. F., Leadlay, P. F.
    Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII.
    J. Mol. Biol. 415: 92-101 (2012). [PMID: 22056329]

[EC 2.4.1.278 created 2012, modified 2014]