EC 2.4.1.274 - Glucosylceramide β-1,4-galactosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.274

Names

Accepted name:
glucosylceramide β-1,4-galactosyltransferase
Other names:
lactosylceramide synthase
uridine diphosphate-galactose:glucosyl ceramide, β 1-4 galactosyltransferase
UDP-Gal:glucosylceramide β1→4galactosyltransferase
GalT-2 [misleading]
UDP-galactose:β-D-glucosyl-(1↔1)-ceramide β-1,4-galactosyltransferase
Systematic name:
UDP-α-D-galactose:β-D-glucosyl-(1↔1)-ceramide 4-β-D-galactosyltransferase

Reaction

Comments:

Involved in the synthesis of several different major classes of glycosphingolipids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Chatterjee, S., Castiglione, E.
    UDPgalactose:glucosylceramide β1→4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.
    Biochim. Biophys. Acta 923: 136-142 (1987). [PMID: 3099851]
  2. Trinchera, M., Fiorilli, A., Ghidoni, R.
    Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide β1→4galactosyltransferase.
    Biochemistry 30: 2719-2724 (1991). [PMID: 1900430]
  3. Chatterjee, S., Ghosh, N., Khurana, S.
    Purification of uridine diphosphate-galactose:glucosyl ceramide, β1-4 galactosyltransferase from human kidney.
    J. Biol. Chem. 267: 7148-7153 (1992). [PMID: 1551920]
  4. Nomura, T., Takizawa, M., Aoki, J., Arai, H., Inoue, K., Wakisaka, E., Yoshizuka, N., Imokawa, G., Dohmae, N., Takio, K., Hattori, M., Matsuo, N.
    Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide β-1,4-galactosyltransferase from rat brain.
    J. Biol. Chem. 273: 13570-13577 (1998). [PMID: 9593693]
  5. Takizawa, M., Nomura, T., Wakisaka, E., Yoshizuka, N., Aoki, J., Arai, H., Inoue, K., Hattori, M., Matsuo, N.
    cDNA cloning and expression of human lactosylceramide synthase.
    Biochim. Biophys. Acta 1438: 301-304 (1999). [PMID: 10320813]

[EC 2.4.1.274 created 2011]