EC 2.4.1.267 - Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol α-1,3-glucosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.267

Names

Accepted name:
dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol α-1,3-glucosyltransferase
Other names:
ALG6
Dol-P-Glc:Man9GlcNAc2-PP-Dol α-1→3-glucosyltransferase
Systematic name:
dolichyl α-D-glucosyl phosphate:D-Man-α-(1→2)-D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→2)-D-Man-α-(1→6)]-D-Man-α-(1→6)]-D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-D-GlcNAc-diphosphodolichol β-1,3-glucosyltransferase

Reaction

Comments:

The successive addition of three glucose residues by EC 2.4.1.267, EC 2.4.1.265 (dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol α-1,3-glucosyltransferase) and EC 2.4.1.256 (dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol α-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0042281
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Reiss, G., te Heesen, S., Zimmerman, J., Robbins, P. W., Aebi, M.
    Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway.
    Glycobiology 6 : 493-498 (1996). [PMID: 8877369]
  2. Runge, K. W., Huffaker, T. C., Robbins, P. W.
    Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway.
    J. Biol. Chem. 259 : 412-417 (1984). [PMID: 6423630]
  3. Westphal, V., Xiao, M., Kwok, P. Y., Freeze, H. H.
    Identification of a frequent variant in ALG6, the cause of congenital disorder of glycosylation-Ic.
    Hum. Mutat. 22 : 420-421 (2003). [PMID: 14517965]

[EC 2.4.1.267 created 2011, modified 2012]