EC - GDP-Man:Man2GlcNAc2-PP-dolichol α-1,6-mannosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
GDP-Man:Man2GlcNAc2-PP-dolichol α-1,6-mannosyltransferase
Other names:
Alg2 mannosyltransferase [ambiguous]
ALG2 (gene name) [ambiguous]
GDP-Man:Man1GlcNAc2-PP-dolichol mannosyltransferase [ambiguous]
GDP-Man:Man2GlcNAc2-PP-Dol α-1,6-mannosyltransferase
Systematic name:
GDP-D-mannose:D-Man-α-(1→3)-D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-D-GlcNAc-diphosphodolichol α-6-mannosyltransferase



The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an α1,3-mannosylation (cf. EC of D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-GlcNAc-diphosphodolichol, followed by an α1,6-mannosylation, to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102704
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Kampf, M., Absmanner, B., Schwarz, M., Lehle, L.
    Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional α1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis.
    J. Biol. Chem. 284 : 11900-11912 (2009). [PMID: 19282279]
  2. O'Reilly, M. K., Zhang, G., Imperiali, B.
    In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis.
    Biochemistry 45 : 9593-9603 (2006). [PMID: 16878994]

[EC created 2011, modified 2012]