EC 2.4.1.217 - Mannosyl-3-phosphoglycerate synthase

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IntEnz Enzyme Nomenclature
EC 2.4.1.217

Names

Accepted name:
mannosyl-3-phosphoglycerate synthase
Other names:
MPG synthase
GDP-mannose:3-phosphoglycerate 3-α-D-mannosyltransferase
Systematic name:
GDP-mannose:3-phospho-D-glycerate 3-α-D-mannosyltransferase

Reaction

Cofactor

Comments:

Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050504
CAS Registry Number: 393512-63-5
UniProtKB/Swiss-Prot:

References

  1. Empadinhas, N., Marugg, J.D., Borges, N., Santos, H. and da Costa, M.S.
    Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key-enzymes.
    J. Biol. Chem. 276: 43580-43588 (2001). [PMID: 11562374]

[EC 2.4.1.217 created 2002]