EC - Lipid-A-disaccharide synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
lipid-A-disaccharide synthase
Other name:
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-β-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase [incorrect]
Systematic name:
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosaminyltransferase



Involved with EC (acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase) and EC (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram negative bacteria.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008915
CAS Registry Number: 105843-81-0
UniProtKB/Swiss-Prot: (258) [show] [UniProt]


  1. Crowell, D.N., Reznikoff, W.S. and Raetz, C.R.H.
    Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase.
    J. Bacteriol. 169 : 5727-5734 (1987). [PMID: 2824445]
  2. Ray, B.L., Painter, G. and Raetz, C.R.H.
    The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli.
    J. Biol. Chem. 259 : 4852-4859 (1984).
  3. Metzger, L. E., Raetz, C. R.
    Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein.
    Biochemistry 48 : 11559-11571 (2009). [PMID: 19883124]
  4. Bohl, T. E., Shi, K., Lee, J. K., Aihara, H.
    Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli.
    Nat Commun 9 : 377 (2018). [PMID: 29371662]

[EC created 1990, modified 2021]