EC 2.4.1.182
- Lipid-A-disaccharide synthase
IntEnz Enzyme Nomenclature
EC 2.4.1.182
Names
Accepted name:
lipid-A-disaccharide synthase
Other
name:
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-β-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase
[incorrect]
Systematic name:
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosamine 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxyacyl]-α-D-glucosaminyltransferase
Reaction
-
a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + a lipid X = UDP + a lipid A disaccharide
Comments:
Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram negative bacteria.
Links to other databases
CAS Registry Number:
105843-81-0
LPXB1_LEGPA
LPXB1_LEGPH
LPXB1_LEGPL
LPXB2_LEGPA
LPXB2_LEGPH
LPXB2_LEGPL
LPXB_ACIAD
LPXB_ACIC5
LPXB_ACTP2
LPXB_ACTP7
LPXB_ACTPJ
LPXB_AERHH
LPXB_ALCBS
LPXB_ALIF1
LPXB_ALIFM
LPXB_ALISL
LPXB_ALKEH
LPXB_ALTMD
LPXB_ANAD2
LPXB_ANADE
LPXB_ANASK
LPXB_AQUAE
LPXB_ARATH
LPXB_AROAE
LPXB_AZOSB
LPXB_AZOVD
LPXB_BLOFL
LPXB_BLOPB
LPXB_BORA1
LPXB_BORBR
LPXB_BORPA
LPXB_BORPD
LPXB_BORPE
LPXB_BRADU
LPXB_BURA4
LPXB_BURCA
LPXB_BURCC
LPXB_BURCH
LPXB_BURCJ
LPXB_BURCM
LPXB_BURL3
LPXB_BURM1
LPXB_BURM7
LPXB_BURM9
LPXB_BURMA
LPXB_BURMS
LPXB_BURP0
LPXB_BURP1
LPXB_BURP6
LPXB_BURPS
LPXB_BURTA
LPXB_BURVG
LPXB_CAMJ8
LPXB_CAMJE
LPXB_CAMJR
LPXB_CELJU
LPXB_CHLAB
LPXB_CHLCV
LPXB_CHLFF
LPXB_CHLMU
LPXB_CHLPN
LPXB_CHLTA
LPXB_CHLTR
LPXB_CHRSD
LPXB_CHRVO
LPXB_CITK8
LPXB_COLP3
LPXB_COXB1
LPXB_COXB2
LPXB_COXBN
LPXB_COXBR
LPXB_COXBU
LPXB_CUPMC
LPXB_CUPPJ
LPXB_DECAR
LPXB_DESPS
LPXB_ECO24
LPXB_ECO27
LPXB_ECO45
LPXB_ECO55
LPXB_ECO57
LPXB_ECO5E
LPXB_ECO7I
LPXB_ECO81
LPXB_ECO8A
LPXB_ECOBW
LPXB_ECODH
LPXB_ECOHS
LPXB_ECOK1
LPXB_ECOL5
LPXB_ECOL6
LPXB_ECOLC
LPXB_ECOLI
LPXB_ECOLU
LPXB_ECOSE
LPXB_ECOSM
LPXB_ECOUT
LPXB_ENT38
LPXB_ERWT9
LPXB_ESCF3
LPXB_FRAP2
LPXB_FRAT1
LPXB_FRATF
LPXB_FRATH
LPXB_FRATM
LPXB_FRATN
LPXB_FRATO
LPXB_FRATT
LPXB_FRATW
LPXB_GEOLS
LPXB_GEOMG
LPXB_GEOSL
LPXB_GLOC7
LPXB_GLUOX
LPXB_GRABC
LPXB_HAEDU
LPXB_HAEI8
LPXB_HAEIE
LPXB_HAEIG
LPXB_HAEIN
LPXB_HAEPS
LPXB_HAES1
LPXB_HAHCH
LPXB_HELAH
LPXB_HELP2
LPXB_HELPG
LPXB_HELPH
LPXB_HELPJ
LPXB_HELPS
LPXB_HELPY
LPXB_HISS2
LPXB_HYDCU
LPXB_IDILO
LPXB_KLEP3
LPXB_KLEP7
LPXB_KORVE
LPXB_MAGMM
LPXB_MAGSA
LPXB_MANSM
LPXB_METFK
LPXB_MYXXD
LPXB_NEIG1
LPXB_NEIMA
LPXB_NEIMB
LPXB_NEIMF
LPXB_NITHX
LPXB_NITOC
LPXB_NITWN
LPXB_PARP8
LPXB_PARPJ
LPXB_PARXL
LPXB_PASMU
LPXB_PECAS
LPXB_PECCP
LPXB_PERMH
LPXB_PHOLL
LPXB_PHOPR
LPXB_PROM3
LPXB_PROMI
LPXB_PROMM
LPXB_PSE14
LPXB_PSEA7
LPXB_PSEA8
LPXB_PSEAB
LPXB_PSEAE
LPXB_PSEE4
LPXB_PSEF5
LPXB_PSEFS
LPXB_PSEMY
LPXB_PSEP1
LPXB_PSEPF
LPXB_PSEPG
LPXB_PSEPK
LPXB_PSEPW
LPXB_PSESM
LPXB_PSET1
LPXB_PSEU2
LPXB_PSYIN
LPXB_RALSO
LPXB_RHOCS
LPXB_RHOFT
LPXB_RHOP2
LPXB_RHOPA
LPXB_RHOPB
LPXB_RICAH
LPXB_RICB8
LPXB_RICBR
LPXB_RICCK
LPXB_RICCN
LPXB_RICFE
LPXB_RICPR
LPXB_RICTY
LPXB_RUEPO
LPXB_SACD2
LPXB_SALA4
LPXB_SALAR
LPXB_SALCH
LPXB_SALDC
LPXB_SALEP
LPXB_SALG2
LPXB_SALHS
LPXB_SALNS
LPXB_SALPA
LPXB_SALPB
LPXB_SALPC
LPXB_SALPK
LPXB_SALSV
LPXB_SALTI
LPXB_SALTY
LPXB_SERP5
LPXB_SHEAM
LPXB_SHEB2
LPXB_SHEFN
LPXB_SHEHH
LPXB_SHELP
LPXB_SHEON
LPXB_SHEPA
LPXB_SHEPC
LPXB_SHESA
LPXB_SHESH
LPXB_SHESM
LPXB_SHESR
LPXB_SHESW
LPXB_SHEWM
LPXB_SHIB3
LPXB_SHIBS
LPXB_SHIDS
LPXB_SHIF8
LPXB_SHIFL
LPXB_SHISS
LPXB_SODGM
LPXB_SOLUE
LPXB_SULSY
LPXB_SYNAS
LPXB_SYNC1
LPXB_SYNY3
LPXB_THIDA
LPXB_VEREI
LPXB_VIBC3
LPXB_VIBCB
LPXB_VIBCH
LPXB_VIBCM
LPXB_VIBPA
LPXB_VIBVU
LPXB_VIBVY
LPXB_WIGBR
LPXB_XANAC
LPXB_XANC5
LPXB_XANC8
LPXB_XANCP
LPXB_XANOM
LPXB_XANOR
LPXB_XYLF2
LPXB_XYLFA
LPXB_XYLFM
LPXB_XYLFT
LPXB_YERPE
LPXB_YERPS
References
-
Crowell, D.N., Reznikoff, W.S. and Raetz, C.R.H.
Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase.
J. Bacteriol.
169
:
5727-5734
(1987).
[PMID:
2824445]
-
Ray, B.L., Painter, G. and Raetz, C.R.H.
The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli.
J. Biol. Chem.
259
:
4852-4859
(1984).
-
Metzger, L. E., Raetz, C. R.
Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein.
Biochemistry
48
:
11559-11571
(2009).
[PMID:
19883124]
-
Bohl, T. E., Shi, K., Lee, J. K., Aihara, H.
Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli.
Nat Commun
9
:
377
(2018).
[PMID:
29371662]
[EC 2.4.1.182 created 1990, modified 2021]