EC - Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
Other names:
N-acetylgalactosaminyltransferase II
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-β-D-galactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase
chondroitin synthase
glucuronyl-N-acetylgalactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II
UDP-N-acetyl-D-galactosamine:β-D-glucuronosyl-(1→3)-N-acetyl-β-D-galactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
Systematic name:
UDP-N-acetyl-α-D-galactosamine:β-D-glucuronosyl-(1→3)-N-acetyl-β-D-galactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase



Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-β-glucuronosyltransferase (EC activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047238
CAS Registry Number: 96189-40-1
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Rohrmann, K., Niemann, R. and Buddecke, E.
    Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate.
    Eur. J. Biochem. 148 : 463-469 (1985). [PMID: 3922754]
  2. Kitagawa, H., Uyama, T. and Sugahara, K.
    Molecular cloning and expression of a human chondroitin synthase.
    J. Biol. Chem. 276 : 38721-38726 (2001). [PMID: 11514575]
  3. DeAngelis, P.L. and Padgett-McCue, A.J.
    Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.
    J. Biol. Chem. 275 : 24124-24129 (2000). [PMID: 10818104]
  4. Ninomiya, T., Sugiura, N., Tawada, A., Sugimoto, K., Watanabe, H. and Kimata, K.
    Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.
    J. Biol. Chem. 277 : 21567-21575 (2002). [PMID: 11943778]

[EC created 1989, modified 2002]