EC 2.4.1.175 - Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.4.1.175
Names
Accepted name:
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
Other
names:
N-acetylgalactosaminyltransferase II
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-β-D-galactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase
chondroitin synthase
glucuronyl-N-acetylgalactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II
UDP-N-acetyl-D-galactosamine:β-D-glucuronosyl-(1→3)-N-acetyl-β-D-galactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-β-D-galactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase
chondroitin synthase
glucuronyl-N-acetylgalactosaminylproteoglycan β-1,4-N-acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II
UDP-N-acetyl-D-galactosamine:β-D-glucuronosyl-(1→3)-N-acetyl-β-D-galactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
Systematic name:
UDP-N-acetyl-α-D-galactosamine:β-D-glucuronosyl-(1→3)-N-acetyl-β-D-galactosaminyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
Reactions
- (1) UDP-N-acetyl-alpha-D-galactosamine + protein-3-O-(beta-D-GlcA-(1right3)-beta-D-GalNAc-(1right4)-beta-D-GlcA-(1right3)-beta-D-Gal-(1right3)-beta-D-Gal-(1right4)-beta-D-Xyl)-L-serine = UDP + protein-3-O-(beta-D-GalNAc-(1right4)-beta-D-GlcA-(1right3)-beta-D-GalNAc-(1right4)-beta-D-GlcA-(1right3)-beta-D-Gal-(1right3)-beta-D-Gal-(1right4)-beta-D-Xyl)-L-serine
- (2) UDP-N-acetyl-alpha-D-galactosamine + protein-3-O-(beta-D-GlcA-(1right3)-[beta-D-GalNAc-(1right4)-beta-D-GlcA-(1right3)]n-beta-D-GalNAc-(1right4)-beta-D-GlcA-(1right3)-beta-D-Gal-(1right3)-beta-D-Gal-(1right4)-beta-D-Xyl)-L-serine = UDP + protein-3-O-([beta-D-GalNAc-(1right4)-beta-D-GlcA-(1right3)]n+1-beta-D-GalNAc-(1right4)-beta-D-GlcA-(1right3)-beta-D-Gal-(1right3)-beta-D-Gal-(1right4)-beta-D-Xyl)-L-serine
Comments:
Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-β-glucuronosyltransferase (EC 2.4.1.226) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0047238
CAS Registry Number:
96189-40-1
References
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Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate.Eur. J. Biochem. 148 : 463-469 (1985). [PMID: 3922754]
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Molecular cloning and expression of a human chondroitin synthase.J. Biol. Chem. 276 : 38721-38726 (2001). [PMID: 11514575]
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Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.J. Biol. Chem. 275 : 24124-24129 (2000). [PMID: 10818104]
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Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4.J. Biol. Chem. 277 : 21567-21575 (2002). [PMID: 11943778]
[EC 2.4.1.175 created 1989, modified 2002]