EC 2.4.1.174 - Glucuronylgalactosylproteoglycan 4-β-N-acetylgalactosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.174

Names

Accepted name:
glucuronylgalactosylproteoglycan 4-β-N-acetylgalactosaminyltransferase
Other names:
N-acetylgalactosaminyltransferase I
glucuronylgalactosylproteoglycan β-1,4-N-acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I
UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-β-D-galactosyl-proteoglycan β-1,4-N-acetylgalactosaminyltransferase
UDP-N-acetyl-D-galactosamine:D-glucuronyl-(1→3)-β-D-galactosyl-proteoglycan 4-β-N-acetylgalactosaminyltransferase
Systematic name:
UDP-N-acetyl-D-galactosamine:[protein]-3-O-(β-D-GlcA-(1→3)-β-D-Gal-(1→3)-β-D-Gal-(1→4)-β-D-Xyl)-L-serine 4-β-N-acetylgalactosaminyltransferase (configuration-inverting)

Reaction

Comments:

Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047237
CAS Registry Number: 96189-39-8
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Rohrmann, K., Niemann, R. and Buddecke, E.
    Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate.
    Eur. J. Biochem. 148 : 463-469 (1985). [PMID: 3922754]
  2. Uyama, T., Kitagawa, H., Tamura, Ji J. and Sugahara, K.
    Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.
    J. Biol. Chem. 277 : 8841-8846 (2002). [PMID: 11788602]

[EC 2.4.1.174 created 1989, modified 2002]