EC - Glucuronosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
1-naphthol glucuronyltransferase
17-OH steroid UDPGT
17β-hydroxysteroid UDP-glucuronosyltransferase
3-OH androgenic UDPGT
3α-hydroxysteroid UDP-glucuronosyltransferase
4-hydroxybiphenyl UDP-glucuronosyltransferase
4-methylumbelliferone UDP-glucuronosyltransferase
4-nitrophenol UDP-glucuronyltransferase
4-nitrophenol UDPGT
p-hydroxybiphenyl UDP glucuronyltransferase
p-nitrophenol UDP-glucuronosyltransferase
p-nitrophenol UDP-glucuronyltransferase
p-phenylphenol glucuronyltransferase
UDP glucuronate-estradiol-glucuronosyltransferase
UDP glucuronate-estriol glucuronosyltransferase
UDP glucuronic acid transferase
UDP glucuronosyltransferase
UDP glucuronyltransferase
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase
UDP-glucuronate-bilirubin glucuronyltransferase
UDPGA transferase
UDPglucuronate β-D-glucuronosyltransferase (acceptor-unspecific)
bilirubin UDP-glucuronosyltransferase
bilirubin UDPGT
bilirubin glucuronyltransferase
bilirubin monoglucuronide glucuronyltransferase
bilirubin uridine diphosphoglucuronyltransferase
ciramadol UDP-glucuronyltransferase
estriol UDPglucuronosyltransferase
estrone UDPglucuronosyltransferase
morphine glucuronyltransferase
uridine 5'-diphosphoglucuronyltransferase
uridine diphosphate glucuronyltransferase
uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase
uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase
uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase
uridine diphosphoglucuronate-estradiol glucuronosyltransferase
uridine diphosphoglucuronate-estriol 16α-glucuronosyltransferase
uridine diphosphoglucuronate-estriol glucuronosyltransferase
uridine diphosphoglucuronosyltransferase
uridine diphosphoglucuronyltransferase
UDP-glucuronate β-D-glucuronosyltransferase (acceptor-unspecific)
Systematic name:
UDP-α-D-glucuronate β-D-glucuronosyltransferase (acceptor-unspecific; conformation-inverting)



This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC, EC, EC, EC, EC, EC, EC and EC A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00359
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015020
CAS Registry Number: 9030-08-4
UniProtKB/Swiss-Prot: (74) [show] [UniProt]


  1. Bock, K.W., Burchell, B., Dutton, G.J., Hanninen, O., Mulder, G.J., Owens, I.S., Siest, G. and Jephly, T.R.
    UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions.
    Biochem. Pharmacol. 32: 953-955 (1983). [PMID: 6404284]
  2. Bock, K.W., Josting, D., Lilienblum, W. and Pfeil, H.
    Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital.
    Eur. J. Biochem. 98: 19-26 (1979). [PMID: 111930]
  3. Burchell, B.
    Identification and purification of multiple forms of UDP-glucuronosyltransferase.
    Rev. Biochem. Toxicol. 3: 1-32 (1981).
  4. Dutton, G.J
    Glucuronidation of Drugs and Other Compounds, C.R.C. Press, Boca Raton, Florida, 1980
  5. Green, M.D., Falany, C.N., Kirkpatrick, R.B. and Tephly, T.R.
    Strain differences in purified rat hepatic 3α-hydroxysteroid UDP-glucuronosyltransferase.
    Biochem. J. 230: 403-409 (1985). [PMID: 3931633]
  6. Jansen, P.L.M.
    The enzyme-catalyzed formation of bilirubin diglucuronide by a solublized preparation from cat liver microsomes.
    Biochim. Biophys. Acta 338: 170-182 (1974).

[EC created 1961 (EC, EC and EC all created 1972; EC, EC and EC all created 1976; EC and EC both created 1983, all incorporated 1984)]