EC 2.4.1.153 - UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.153

Names

Accepted name:
UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminyltransferase
Other names:
UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase
dolichyl-phosphate α-N-acetylglucosaminyltransferase
dolichyl-phosphate acetylglucosaminyltransferase
uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase
aglK (gene name)
UDP-N-acetyl-D-glucosamine:dolichyl-phosphate α-N-acetyl-D-glucosaminyltransferase
Systematic name:
UDP-N-acetyl-α-D-glucosamine:dolichyl-phosphate α-N-acetyl-D-glucosaminyltransferase

Reaction

Comments:

The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, initiates N-linked glycosylation in that organism. The enzyme differs from the eukaryotic enzyme, which leaves one additional phosphate group on the dolichyl product (cf. EC 2.7.8.15, UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004166
CAS Registry Number: 63363-73-5
UniProtKB/Swiss-Prot:

References

  1. Larkin, A., Chang, M. M., Whitworth, G. E., Imperiali, B.
    Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis.
    Nat. Chem. Biol. 9 : 367-373 (2013). [PMID: 23624439]

[EC 2.4.1.153 created 1984, modified 2015]